2-Methoxyestradiol-d5

Cat. No.: IBDI-432253

2-Methoxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa.

Product Details

Target	Microtubule/Tubulin | Reactive Oxygen Species | Apoptosis | Autophagy | Endogenous Metabolite
Molecular Weight	307.44
Synonyms	2-ME2-d5, NSC-659853-d5
SMILES	C[[email protected]@]12[[email protected]](CC([2H])([2H])[[email protected]]2([2H])O)([H])[[email protected]@]3([H])[[email protected]@](CC1)([H])C4=C([2H])C(OC)=C(O)C([2H])=C4CC3

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.