4-Hydroxyestradiol

Cat. No.: IBDI-432256

4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM.

Product Details

Target	Drug Metabolite | Endogenous Metabolite
Molecular Weight	288.38
Appearance	Solid
Synonyms	4-Hydroxy-17β-estradiol
SMILES	C[[email protected]@]12[[email protected]](CC[[email protected]@H]2O)([H])[[email protected]@](CCC3=C4O)([H])[[email protected]@](CC1)([H])C3=CC=C4O
Purity	≥99.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.