7ß,27-Dihydroxycholesterol

Cat. No.: IBDI-432311

7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4 + Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1.

Product Details

Target	ROR
Molecular Weight	418.65
Appearance	Solid
Synonyms	7β, 27-OHC
SMILES	C[[email protected]@H](CO)CCC[[email protected]@H](C)[[email protected]]1CC[[email protected]@]2([H])[[email protected]]3([H])[[email protected]@H](O)C=C4C[[email protected]@H](O)CC[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]]12C
Purity	≥99.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.