Almorexant

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Cat. No.: IBDI-433662

Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca 2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Orexin Receptor (OX Receptor) \| Calcium Channel \| Caspase \| Apoptosis
Molecular Weight	512.56
Appearance	Solid
Synonyms	ACT 078573
SMILES	CNC([[email protected]@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[[email protected]@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O
Purity	99.71%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.