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Alrizomadlin

Cat. No.: IBDI-435978

Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner.

Size (Solid):

Product Details

Target MDM-2/p53 | E1/E2/E3 Enzyme | Apoptosis
Molecular Weight 642.59
Appearance Solid
Synonyms APG-115, AA-115
SMILES O=C(N1)[[email protected]]([[email protected]@H](C(C=CC=C2Cl)=C2F)[[email protected]@H]3C(NC45CCC(C(O)=O)(CC5)CC4)=O)(C(C1=C6)=CC=C6Cl)C7(CCCCC7)N3CC
Purity 98.05%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Powder: -20°C/3 years; 4°C/2 years
In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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