Androgen receptor antagonist 1

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Androgen receptor antagonist 1

Cat. No.: IBDI-435571

Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC50 of 59 nM. Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Androgen Receptor \| Ligands for Target Protein for PROTAC
Molecular Weight	416.90
Appearance	Solid
SMILES	O=C(C1=CN(CCO)N=C1)N[[email protected]]2C(C)(C)[[email protected]](OC3=CC=C(C#N)C(Cl)=C3)C2(C)C
Purity	99.39%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.