Anti-TAB2 antibody - BSA and Azide free (Capture)

Overview

Product Type	TLR Signaling
Host Species	Rabbit
Species Reactivity	Reacts with: Human
Application	Sandwich ELISA

Properties

Carrier Free	Yes
Purity	Protein A purified
Clonality	Monoclonal
Conjugate	Unconjugated
Isotype	IgG

Target

Function	Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
Tissue Specificity	Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
Sequence Similarities	Contains 1 CUE domain. Contains 1 RanBP2-type zinc finger.
Cellular Localization	Membrane. Cytoplasm > cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.

Storage & Handling

Storage

Store at +4°C. Please refer to protocols.