Anti-Transferrin Receptor antibody - BSA and Azide free (Capture)

Overview

Product Type	Cell Type Markers
Host Species	Rabbit
Species Reactivity	Reacts with: Human
Application	Sandwich ELISA

Properties

Carrier Free	Yes
Purity	Protein A purified
Clonality	Monoclonal
Conjugate	Unconjugated
Isotype	IgG

Target

Function	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Sequence Similarities	Belongs to the peptidase M28 family. M28B subfamily. Contains 1 PA (protease associated) domain.
Cellular Localization	Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Storage & Handling

Storage

Store at +4°C. Please refer to protocols.