Antiproliferative agent-23

Cat. No.: IBDI-435323

Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity.

Product Details

Target	Microtubule/Tubulin | Apoptosis
Molecular Weight	743.93
SMILES	O=C(C1=CC(OC)=C(C(OC)=C1)OC)/C=C/C2=CC=CC3=C2C=CN3CCC(O[Pt](Cl)(Cl)(Cl)([NH3])[NH3])=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.