AT-533

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Cat. No.: IBDI-433054

AT-533 is a potent Hsp90 and HSV inhibitor. AT-533 suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits the activation of the downstream pathways, including Akt/mTOR/p70S6K, Erk1/2 and FAK. AT-533 inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	HSP \| HSV \| HIF/HIF Prolyl-Hydroxylase \| VEGFR \| NF-κB \| ERK \| Akt \| FAK
Molecular Weight	410.51
Appearance	Solid
SMILES	CC1=NN(C2=CC(N[[email protected]@H]3CC[[email protected]](CC3)O)=C(C=C2)C(N)=O)C(CC(C)(C4)C)=C1C4=O
Purity	98.86%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.