Azurocidin Polyclonal Antibody

Target Information

Target Name	Azurocidin
Uniprot ID	P20160
Cellular Localization	Cytoplasmic granule. Cytoplasmic granules of neutrophils.
Immunogen	Recombinant full length protein within Human Azurocidin aa 1-300.
Function	This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

Product Details

Description	Mouse polyclonal antibody to Azurocidin.
Host Species	Mouse
Clonality	Polyclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant full length protein within Human Azurocidin aa 1-300.
Positive Control	Human spleen lysate. Azurocidin transfected 293T cell lysate. Human lymph node tissue. HeLa cells.
Application	ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7.4 Constituent: 99% PBS
Handling	Avoid freeze-thaw cycles.