BACE1/2-IN-1

Cat. No.: IBDI-434510

BACE1/2-IN-1 (compound 34) is a potent BACE1 and BACE2 inhibitor, with an IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability.

Product Details

Target	Beta-secretase | Amyloid-β
Molecular Weight	401.57
SMILES	NC1=N[[email protected]](CN(C2=NC=CC=N2)C3)([[email protected]]4([H])C[[email protected]]4(C(C)(C)OC[[email protected]@H]5C[[email protected]]5C)[H])[[email protected]@H]3CS1

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.