Bafilomycin A1

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Cat. No.: IBDI-430218

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H +-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.

Size (Solid):

Product Details

Target	Proton Pump \| Autophagy \| Antibiotic \| Bacterial \| Apoptosis
Molecular Weight	622.83
Appearance	Solid
Synonyms	BafA1
SMILES	C[[email protected]]([[email protected]](O[[email protected]@H]1C(C)C)(C[[email protected]@H](O)[[email protected]@H]1C)O)[[email protected]](O)[[email protected]@H]([[email protected]](OC(/C(OC)=C/C(C)=C\[[email protected]@H](C)[[email protected]@H](O)[[email protected]@H](C)C2)=O)([H])[[email protected]](/C=C/C=C2\C)OC)C
Structure Classification	Antibiotics>Macrolide Antibiotics
Purity	98.92%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.