Bcl-2-IN-6

Cat. No.: IBDI-436345

Bcl-2-IN-6 (compound 10) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC50 values of 20.91, 22.30, 42.29, and 48.00 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively.

Product Details

Target	Bcl-2 Family | MDM-2/p53 | Caspase | Apoptosis
Molecular Weight	524.61
SMILES	O=C(NC1=CC=CC(CC)=C1)CSC(N2C3=CC=C(S(=O)(N)=O)C=C3)=NC4=C(C=CC=C4OC)C2=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.