BI-0474

Cat. No.: IBDI-434199

BI-0474 is a potent KRAS G12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.

Product Details

Target	Ras
Molecular Weight	587.74
SMILES	N#CC1=C(N)SC2=C1[[email protected]@](C)(C3=NC(C4=NC(N5[[email protected]@H](C)CN(C)CC5)=CC(N6CCN(C(C=C)=O)CC6)=C4)=NO3)CCC2

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.