Birinapant
Cat. No.: IBDI-434134
Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP; and cIAP; 1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP; 1 and cIAP; 2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAP; s and abrogates TNF-induced NF-κB activation.
Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution
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Product Details
| Target |
IAP | Apoptosis | HIV |
| Molecular Weight |
806.94 |
| Appearance |
Solid |
| Synonyms |
TL32711 |
| Purity |
99.70% |
Storage & Handling
| Shipping |
Room temperature in continental US. May vary elsewhere. |
| Storage |
Powder: -20°C/3 years; 4°C/2 years
In solvent: -80°C/6 months; -20°C/1 month |
| Regulatory Status |
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. |
! For research use only, not intended for any clinical use.
