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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Birinapant

Cat. No.: IBDI-434134

Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP; and cIAP; 1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP; 1 and cIAP; 2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAP; s and abrogates TNF-induced NF-κB activation.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target IAP | Apoptosis | HIV
Molecular Weight 806.94
Appearance Solid
Synonyms TL32711
SMILES FC1=CC2=C(C=C1)C(C[[email protected]]3N(C([[email protected]@H](NC([[email protected]@H](NC)C)=O)CC)=O)C[[email protected]@H](O)C3)=C(C(N4)=C(C[[email protected]]5N(C([[email protected]@H](NC([[email protected]@H](NC)C)=O)CC)=O)C[[email protected]@H](O)C5)C6=C4C=C(F)C=C6)N2
Purity 99.70%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Powder: -20°C/3 years; 4°C/2 years
In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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