Borrelidin

Cat. No.: IBDI-430221

Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively.

Product Details

Target	CDK | PaRasite | Apoptosis | Antibiotic
Molecular Weight	489.64
Appearance	Solid
Synonyms	Treponemycin
SMILES	O=C([[email protected]]1[[email protected]]([[email protected]](C/C=C/C=C(C#N)\[[email protected]](O)[[email protected]@H](C)C[[email protected]](C)C[[email protected]](C)C[[email protected]](C)[[email protected]@H](O)C2)OC2=O)CCC1)O
Structure Classification	Antibiotics>Macrolide Antibiotics
Purity	≥99.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.