BRD9876
Cat. No.: IBDI-432571
BRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research.
Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution
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Product Details
| Target |
Kinesin | Microtubule/Tubulin |
| Molecular Weight |
234.30 |
| Appearance |
Solid |
| SMILES |
CC(C)(C1=CC2=CC(C#N)=C(C#N)C=C2C=C1)C |
| Purity |
98.33% |
Storage & Handling
| Shipping |
Room temperature in continental US. May vary elsewhere. |
| Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| Regulatory Status |
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. |
! For research use only, not intended for any clinical use.
