Brusatol

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Cat. No.: IBDI-431070

Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent. Brusatol increases cellular apoptosis.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Keap1-Nrf2 \| Apoptosis
Molecular Weight	520.53
Appearance	Solid
Synonyms	NSC 172924
SMILES	CC([[email protected]](C[[email protected]@](O1)2[H])3[H])=C(O)C(C[[email protected]]3(C)[[email protected]]4([H])[[email protected]]2(CO[[email protected]@]5([[email protected]@H](O)[[email protected]@H]4O)C(OC)=O)[[email protected]@]5([H])[[email protected]@H](OC(/C=C(C)/C)=O)C1=O)=O
Structure Classification	Terpenoids>Diterpenoids
Purity	99.89%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.