Cat. No.: IBDA-435111
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Online InquiryTarget Information
| Target Name | C5/C5a |
| Uniprot ID | P01031 |
| Cellular Localization | Secreted. |
| Immunogen | Other Immunogen Type corresponding to Human C5/ C5a. |
| Function | Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). |
Product Details
| Description | Mouse monoclonal antibody to C5 / C5a. |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein G purified |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Other Immunogen Type corresponding to Human C5/ C5a. |
| Positive Control | Recombinant C5 |
| Application | ELISA, FuncS, Inhibition, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Upon delivery aliquot. Store at -20 °C |
| Storage Buffer | Constituent: PBS, 0.1% BSA |
| Handling | Avoid freeze-thaw cycles. |