Cafestol

Cat. No.: IBDI-431050

Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects.

Product Details

Target	ERK | PGE synthase | COX | NF-κB
Molecular Weight	316.43
Appearance	Solid
SMILES	C[[email protected]]12[[email protected]@]3([H])[[email protected]@]4(CC[[email protected]]1([H])C5=C(OC=C5)CC2)C[[email protected]@]([[email protected]](CO)(O)C4)([H])CC3
Structure Classification	Terpenoids> Diterpenoids
Purity	98.98%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.