Calcimycin hemimagnesium

Cat. No.: IBDI-433671

Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis.

Product Details

Target	Bacterial | Fungal | Apoptosis | Autophagy
Molecular Weight	1069.53
Synonyms	A-23187 hemimagnesium, Antibiotic A-23187 hemimagnesium
SMILES	CNC1=CC=C2OC(C[[email protected]@H]3[[email protected]@H](CC[[email protected]@]4(O3)[[email protected]@H](C[[email protected]]([[email protected]](O4)[[email protected]@H](C(C5=CC=CN5)=O)C)C)C)C)=NC2=C1C([O-][Mg+2][O-]C(C6=C7N=C(C[[email protected]]8O[[email protected]]9(O[[email protected]]([[email protected]](C)C(C%10=CC=CN%10)=O)[[email protected]](C)C[[email protected]]9C)CC[[email protected]]8C)OC7=CC=C6NC)=O)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.