Calcimycin

Cat. No.: IBDI-430226

Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis.

Product Details

Target	Bacterial | Fungal | Apoptosis | Autophagy | Antibiotic
Molecular Weight	523.62
Appearance	Solid
Synonyms	A-23187, Antibiotic A-23187
SMILES	O=C(C1=C2N=C(C[[email protected]]3O[[email protected]]4(O[[email protected]]([[email protected]](C)C(C5=CC=CN5)=O)[[email protected]](C)C[[email protected]]4C)CC[[email protected]]3C)OC2=CC=C1NC)O
Structure Classification	Antibiotics>Polyether Antibiotics
Purity	≥99.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.