Cathepsin E Activity Assay Kit (Fluorometric)

Overview

Sample Type	Cell Lysate, Purified protein, Tissue Lysate
Detection Method	Fluorescent
Assay Type	Enzyme activity (quantitative)
Product Type	Macrophage / Inflamm.
Sensitivity	1000 µU
Species Reactivity	Reacts with: Mammals, Other species
Platform	Microplate reader

Target

Function	May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Tissue Specificity	Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
Sequence Similarities	Belongs to the peptidase A1 family.
Cellular Localization	Endosome. The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.

Storage & Handling

Storage	Store at +4°C.
Storage Buffer	Constituent: 100% PBS