Cat. No.: IBDA-434103
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Online InquiryTarget Information
| Target Name | CCL4/MIP-1 Beta |
| Uniprot ID | P13236 |
| Cellular Localization | Secreted. |
| Immunogen | Synthetic peptide within Human CCL4/MIP-1 beta aa 1 to the C-terminus (N terminal). |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
Product Details
| Description | Rabbit monoclonal antibody to CCL4/MIP-1 beta. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Synthetic peptide within Human CCL4/MIP-1 beta aa 1 to the C-terminus (N terminal). |
| Positive Control | THP-1, Raw264.7 |
| Application | ELISA, ICC/IF, IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Upon delivery aliquot. Store at -20 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 49% PBS, 50% Glycerol, 0.05% BSA |
| Handling | Avoid freeze-thaw cycles. |