CCR4 antagonist 2

Cat. No.: IBDI-431421

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca 2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.

Product Details

Target	CCR
Molecular Weight	511.45
SMILES	ClC(C=C(Cl)C=C1)=C1[[email protected]@H](C)N2N=C(C#N)C3=C2N=C(C4=CC[[email protected]](N5[[email protected]](CO)CCC5)[[email protected]](C)C4)C=N3

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.