CD13 Polyclonal Antibody

Target Information

Target Name	CD13
Uniprot ID	P15144
Cellular Localization	Cell membrane. Cytoplasm > cytosol. A soluble form has also been detected.
Immunogen	Recombinant fragment, corresponding to a region within amino acids 455-779 of Human CD13.
Function	Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

Product Details

Description	Rabbit polyclonal antibody to CD13.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment, corresponding to a region within amino acids 455-779 of Human CD13.
Positive Control	HepG2 and Raji cell lysates. H1299 xenograft tissue.
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7 Preservative: 0.01% Thimerosal (Merthiolate) Constituent: 1.21% Tris, 0.75% Glycine, 10% Glycerol
Handling	Avoid freeze-thaw cycles.