Cat. No.: IBDA-432651
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Online InquiryTarget Information
| Target Name | CD146 |
| Uniprot ID | P43121 |
| Cellular Localization | Membrane. |
| Immunogen | Synthetic peptide. |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration. |
Product Details
| Description | Rabbit monoclonal antibody to CD146. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Alexa Fluor® 647 |
| Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Positive Control | IHC-P: Human tonsil and Human breast carcinoma tissues. ICC: A375 cells. Flow Cyt (Intra): A375 cell. |
| Application | Flo, ICC/IF, IHC-P |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C. Store in the dark |
| Storage Buffer | pH: 7.4 Preservative: 0.02% Sodium Azide Constituent: 30% Glycerol, 1% BSA, 68% PBS |
| Handling | Avoid freeze-thaw cycles. |