Cat. No.: IBDA-432667
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Online InquiryTarget Information
| Target Name | CD146 |
| Uniprot ID | P43121 |
| Cellular Localization | Membrane. |
| Immunogen | Recombinant full length protein corresponding to Human CD146. |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration. |
Product Details
| Description | Mouse monoclonal antibody to CD146. |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein A/G purified |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Recombinant full length protein corresponding to Human CD146. |
| Positive Control | IHC-p. Human tonsil and melanoma tissues. |
| Application | IHC-P |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.05% Sodium Azide Constituent: PBS, 0.05% BSA |
| Handling | Avoid freeze-thaw cycles. |