CD146 Monoclonal Antibody

Target Information

Target Name	CD146
Uniprot ID	P43121
Cellular Localization	Membrane.
Immunogen	Tissue, cells or virus corresponding to Human CD146.
Function	Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Product Details

Description	FITC Mouse monoclonal antibody to CD146.
Host Species	Mouse
Clonality	Monoclonal
Purity	Immunogen affinity purified
Isotype	IgG1
Conjugation	FITC
Reactivity	Human
Immunogen	Tissue, cells or virus corresponding to Human CD146.
Positive Control	Human, mouse or dog blood or marrow cells Human intestinal smooth muscle cells Melanoma A2058, SKMEL.3 or A375.S2 cells Normal, primary HUVEC or MVEC cultures Human skin, intestine, ovary tonsil, lymph node, lung or kidney tissue.
Application	Flo

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at 4 °C
Storage Buffer	pH: 7.60 Preservative: 0.1% Sodium Azide Constituent: 1.5% BSA, 1.45% Sodium Chloride, 0.0536% PBS