Cat. No.: IBDA-432671
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Online InquiryTarget Information
| Target Name | CD146 |
| Uniprot ID | P43121 |
| Cellular Localization | Membrane. |
| Immunogen | Synthetic peptide within Human CD146 aa 200-300. |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration. |
Product Details
| Description | Rabbit monoclonal antibody to CD146. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Tissue culture supernatant |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Synthetic peptide within Human CD146 aa 200-300. |
| Positive Control | A375, fetal artery and HUVEC cell lysates. HeLa cells |
| Application | WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.05% Sodium Azide Constituent: 0.1% BSA, 40% Glycerol, 9.85% Tris Glycine, 50% Tissue Culture Supernatant |
| Handling | Avoid freeze-thaw cycles. |