CD146 Monoclonal Antibody

Target Information

Target Name	CD146
Uniprot ID	P43121
Cellular Localization	Membrane.
Immunogen	Other Immunogen Type corresponding to CD146.
Function	Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Product Details

Description	Mouse monoclonal antibody to CD146.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Other Immunogen Type corresponding to CD146.
Application	Flo, ICC/IF, IHC-Fr

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	Constituent: PBS
Handling	Avoid freeze-thaw cycles.