CD146 Polyclonal Antibody

Target Information

Target Name	CD146
Uniprot ID	P43121
Cellular Localization	Membrane.
Immunogen	Recombinant fragment within Human CD146 (C terminal).
Function	Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Product Details

Description	Rabbit polyclonal antibody to CD146 - C-terminal.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Recombinant fragment within Human CD146 (C terminal).
Positive Control	WB: Rat liver extract. HCT 116 whole cell lysate. IHC-P: J5 xenograft. Mouse skin and colon tissues. ICC/IF: HUVEC cells.
Application	ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7 Preservative: 0.01% Thimerosal (Merthiolate) Constituent: 79.99% PBS, 20% Glycerol
Handling	Avoid freeze-thaw cycles.