Cat. No.: IBDA-432026
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Online InquiryTarget Information
| Target Name | CD161 |
| Uniprot ID | Q12918 |
| Cellular Localization | Membrane. |
| Immunogen | Recombinant fragment corresponding to Human CD161 aa 50 to the C-terminus. |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
Product Details
| Description | Mouse monoclonal antibody to CD161 - BSA and Azide Free. |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein A/G purified |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Recombinant fragment corresponding to Human CD161 aa 50 to the C-terminus. |
| Positive Control | WB: HEK-293T transfected with pCMV6-ENTRY CD61 cDNA. IHC-P: Human spleen tissue. |
| Application | IHC-P, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.3 Constituent: PBS |
| Handling | Avoid freeze-thaw cycles. |