Cat. No.: IBDA-432021
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Online InquiryTarget Information
| Target Name | CD161 |
| Uniprot ID | Q12918 |
| Cellular Localization | Membrane. |
| Immunogen | Recombinant fragment (His-T7-tag) corresponding to Human CD161 aa 50-200. |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
Product Details
| Description | Rabbit polyclonal antibody to CD161. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human, Pig |
| Immunogen | Recombinant fragment (His-T7-tag) corresponding to Human CD161 aa 50-200. |
| Positive Control | IHC-P: Human brain, liver, glioma and kidney tissues. WB: HEK-293T cell lysate. Pig muscle and spleen lysates. Recombinant human CD161 protein. |
| Application | IHC-P, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: PBS, 50% Glycerol |
| Handling | Avoid freeze-thaw cycles. |