CD163 Monoclonal Antibody

Target Information

Target Name	CD163
Uniprot ID	Q86VB7
Cellular Localization	Secreted and Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
Immunogen	Synthetic peptide within Human CD163 aa 850-900.
Function	Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Product Details

Description	Rabbit monoclonal antibody to CD163.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human CD163 aa 850-900.
Positive Control	IHC-P: Human liver carcinoma and lung carcinoma tissue. Human lung carcinoma pleural fluid.
Application	IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.8 Preservative: 0.09% Sodium Azide Constituent: 99% Borate Buffered Saline, 0.1% BSA
Handling	Avoid freeze-thaw cycles.