CD33 Monoclonal Antibody - BSA and Azide Free

Target Information

Target Name	CD33
Uniprot ID	P20138
Cellular Localization	Cell membrane.
Immunogen	Synthetic peptide within Human CD33 aa 314-364 (C terminal).
Function	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

Product Details

Description	Rabbit monoclonal antibody to CD33 - BSA and Azide Free.
Host Species	Rabbit
Clonality	Monoclonal
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human CD33 aa 314-364 (C terminal).
Positive Control	IHC-P: Acute Myeloid leukemia tissue. IP: HEL921.7 whole cell lysate.
Application	IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 8.20 Preservative: 0.09% Sodium Azide Constituent: 99% Borate Buffered Saline
Handling	Avoid freeze-thaw cycles.