Cat. No.: IBDA-433491
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Online InquiryTarget Information
| Target Name | CD33 |
| Uniprot ID | P20138 |
| Cellular Localization | Cell membrane. |
| Immunogen | Tissue, cells or virus corresponding to Human CD33. |
| Function | Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). |
Product Details
| Description | Mouse monoclonal antibody to CD33 - BSA and Azide Free. |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein G purified |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Tissue, cells or virus corresponding to Human CD33. |
| Positive Control | Human dendritic and mast cells. Human lymph nodes and tonsils. |
| Application | Flo, FuncS, ICC/IF |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Constituent: 100% PBS |
| Handling | Avoid freeze-thaw cycles. |