Cat. No.: IBDA-433476
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Online InquiryTarget Information
| Target Name | CD33 |
| Uniprot ID | P20138 |
| Cellular Localization | Cell membrane. |
| Immunogen | Tissue, cells or virus. |
| Function | Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). |
Product Details
| Description | Mouse monoclonal antibody to CD33 - BSA and Azide Free. |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Tissue, cells or virus. |
| Positive Control | Flow Cyt: Human peripheral blood mononuclear cells (PBMC). ICC: HL-60 cells |
| Application | Flo, ICC/IF |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | pH: 7.2 Constituent: PBS |
| Handling | Do not freeze. |