CD33 Monoclonal Antibody

Target Information

Target Name	CD33
Uniprot ID	P20138
Cellular Localization	Cell membrane.
Immunogen	Synthetic peptide within Human CD33 aa 1-100.
Function	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

Product Details

Description	Rabbit monoclonal antibody to CD33.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human CD33 aa 1-100.
Positive Control	WB: THP1 cell lysate, U937 cell lysate, HL 60 cell lysate, HepG2 whole cell lysate, HeLa whole cell lysate Flow Cyt: THP1 cells
Application	Flo, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: 40% Glycerol, 0.05% BSA, 59% PBS
Handling	Avoid freeze-thaw cycles.