Cat. No.: IBDA-433479
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Online InquiryTarget Information
| Target Name | CD33 |
| Uniprot ID | P20138 |
| Cellular Localization | Cell membrane. |
| Immunogen | Full length protein. |
| Function | Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). |
Product Details
| Description | Rabbit monoclonal antibody to CD33 - Low Endotoxin, Azide Free. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Full length protein. |
| Positive Control | WB: THP1 cell lysate, U937 cell lysate, HL 60 cell lysate, HepG2 whole cell lysate, HeLa whole cell lysate |
| Application | IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | pH: 7.2 Constituent: PBS |
| Handling | Do not freeze. |