CD33 Monoclonal Antibody

Target Information

Target Name	CD33
Uniprot ID	P20138
Cellular Localization	Cell membrane.
Immunogen	Recombinant full length protein (Fc-tag) corresponding to CD33.
Function	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

Product Details

Description	Mouse monoclonal antibody to CD33.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant full length protein (Fc-tag) corresponding to CD33.
Positive Control	IHC-P: Human tonsil FFPE tissue sections
Application	IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	Constituent: PBS
Handling	Avoid freeze-thaw cycles.