Cat. No.: IBDA-433487
Size:
Online InquiryTarget Information
| Target Name | CD33 |
| Uniprot ID | P20138 |
| Cellular Localization | Cell membrane. |
| Immunogen | Synthetic peptide within Human CD33 aa 250-350 conjugated to keyhole limpet haemocyanin. |
| Function | Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). |
Product Details
| Description | Rabbit polyclonal antibody to CD33. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Synthetic peptide within Human CD33 aa 250-350 conjugated to keyhole limpet haemocyanin. |
| Positive Control | Human gastric carcinoma tissue. Flow Cyt (Intra): U937 cells |
| Application | Flo, IHC-P |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.09% Sodium Azide Constituent: 50% Glycerol, 0.1% BSA, 49% Water |
| Handling | Avoid freeze-thaw cycles. |