CD44v6 Monoclonal Antibody

Target Information

Target Name	CD44v6
Uniprot ID	P16070
Cellular Localization	Membrane. Colocalizes with actin in membrane protrusions at wounding edges.
Immunogen	Recombinant fragment corresponding to Human CD44v6.
Function	Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Product Details

Description	Mouse monoclonal antibody to CD44v6.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment corresponding to Human CD44v6.
Positive Control	IHC-P: Human breast carcinoma, skin and breast tissue.
Application	IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: PBS, 0.05% BSA, 40% Glycerol
Handling	Avoid freeze-thaw cycles.