CD45 Monoclonal Antibody

Target Information

Target Name	CD45
Uniprot ID	P08575
Cellular Localization	Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts.
Immunogen	Tissue, cells or virus corresponding to Human CD45.
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.

Product Details

Description	Mouse monoclonal antibody to CD45 - Hematopoietic Stem Cell Marker.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG2a
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Tissue, cells or virus corresponding to Human CD45.
Positive Control	IHC-P: Human tonsil (normal) tissue. ICC/IF: Jurkat cells. Flow Cyt: Jurkat cells, whole blood.
Application	Flo, ICC/IF, IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.