Cat. No.: IBDA-434424
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Online InquiryTarget Information
| Target Name | CD45 |
| Uniprot ID | P08575 |
| Cellular Localization | Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts. |
| Immunogen | Synthetic peptide, corresponding to a region within amino acids 914-1004 of Human CD45 . |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. |
Product Details
| Description | Rabbit polyclonal antibody to CD45. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Synthetic peptide, corresponding to a region within amino acids 914-1004 of Human CD45 . |
| Positive Control | 293T and A431 whole cell lysate. Mouse ESC D3 cells |
| Application | ICC/IF |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Upon delivery aliquot. Store at -20 °C or -80 °C |
| Storage Buffer | pH: 7 Preservative: 0.025% Proclin 300 Constituent: 78% PBS, 1% BSA, 20% Glycerol |
| Handling | Avoid freeze-thaw cycles. |