Cat. No.: IBDA-434460
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Online InquiryTarget Information
| Target Name | CD45RC |
| Uniprot ID | P08575 |
| Cellular Localization | Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts. |
| Immunogen | Tissue, cells or virus corresponding to Rat CD45RC. |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. |
Product Details
| Description | Mouse monoclonal antibody to CD45RC. |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein G purified |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Reactivity | Rat, Human |
| Immunogen | Tissue, cells or virus corresponding to Rat CD45RC. |
| Positive Control | IHC-Fr: Frozen rat spleen. IHC-P: Rat spleen tissue. |
| Application | Flo, IHC-Fr, IHC-P |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | Preservative: 0.02% Sodium Azide Constituent: PBS |
| Handling | Avoid freeze-thaw cycles. |