Cat. No.: IBDA-433861
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Online InquiryTarget Information
| Target Name | CD46 |
| Uniprot ID | P15529 |
| Cellular Localization | Cytoplasmic vesicle > secretory vesicle > acrosome inner membrane. Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide. |
| Function | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. |
Product Details
| Description | Rabbit monoclonal antibody to CD46 - BSA and Azide Free (Capture). |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Application | sELISA |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | Constituent: 100% PBS |