CD59 Polyclonal Antibody

Target Information

Target Name	CD59
Uniprot ID	P13987
Cellular Localization	Cell membrane. Secreted. Soluble form found in a number of tissues.
Immunogen	Recombinant fragment: YNCPNPTADC KTAVNCSSDF DACLITKAGL QVYNKCWKFE HCNFNDVTTR LRENELTYYC CKKDLCNFNE QLEN, corresponding to amino acids 29-102 of Human CD59 (BC001506).
Function	Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

Product Details

Description	Rabbit polyclonal antibody to CD59.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment: YNCPNPTADC KTAVNCSSDF DACLITKAGL QVYNKCWKFE HCNFNDVTTR LRENELTYYC CKKDLCNFNE QLEN, corresponding to amino acids 29-102 of Human CD59 (BC001506).
Positive Control	Human fetal brain tissue
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.02% Sodium Azide Constituent: 98% PBS, 1% BSA
Handling	Avoid freeze-thaw cycles.