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CD59 Polyclonal Antibody

Cat. No.: IBDA-433992

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Target Information

Target Name CD59
Uniprot ID P13987
Cellular Localization Cell membrane. Secreted. Soluble form found in a number of tissues.
Immunogen Recombinant fragment: YNCPNPTADC KTAVNCSSDF DACLITKAGL QVYNKCWKFE HCNFNDVTTR LRENELTYYC CKKDLCNFNE QLEN, corresponding to amino acids 29-102 of Human CD59 (BC001506).
Function Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

Product Details

Description Rabbit polyclonal antibody to CD59.
Host Species Rabbit
Clonality Polyclonal
Purity Immunogen affinity purified
Isotype IgG
Conjugation Unconjugated
Reactivity Human
Immunogen Recombinant fragment: YNCPNPTADC KTAVNCSSDF DACLITKAGL QVYNKCWKFE HCNFNDVTTR LRENELTYYC CKKDLCNFNE QLEN, corresponding to amino acids 29-102 of Human CD59 (BC001506).
Positive Control Human fetal brain tissue
Application IHC-P, WB

Storage & Handling

Shipping Shipped at 4 °C.
Storage Store at -20 °C
Storage Buffer pH: 7.20
Preservative: 0.02% Sodium Azide
Constituent: 98% PBS, 1% BSA
Handling Avoid freeze-thaw cycles.
! For research use only, not intended for any clinical use.