CDH1/E Cadherin Monoclonal Antibody

Target Information

Target Name	CDH1/E Cadherin
Synonyms	CDH1 | CD324 | CDHE | Cell-CAM 120/80 | E Cadherin | E-Cadherin | ECAD | Epithelial cadherin | Arc-1 | UVO | Cadherin-1 | CAM 120/80 | CD324 antigen | LCAM | Uvomorulin
Uniprot ID	P12830
Immunogen	Recombinant full-length human E-Cadherin protein. Antigen Molecular Weight: 120-80 kDa (Mature) - 135 kDa (Precursor).

Product Details

Description	E Cadherin antibody is an unconjugated mouse recombinant monoclonal antibody to human E Cadherin (CDH1).
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein A/G purified
Conjugation	Unconjugated
Modifications	Azide-free, Carrier-free. Also available Unmodified.
Reactivity	Human
Specificity	Recognizes a protein of 120-80 kDa , identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
Immunogen	Recombinant full-length human E-Cadherin protein. Antigen Molecular Weight: 120-80 kDa (Mature) - 135 kDa (Precursor).
Application	IF, IHC-P, WB

Storage & Handling

Shipping	Shipped on dry ice.
Storage	Store at -20 °C or -80 °C
Storage Buffer	10 mM PBS
Handling	Avoid freeze-thaw cycles.